UniSa will investigate through a LCA the environmental impacts for the synthesis of ketals, DPA and GVL-RP considering the optimized reaction conditions. This approach will be adopted to compare theenvironmental-economic-social impacts among batch and in-flow synthesis for all the investigated processes. All primary data concerning laboratory experiments, such as reagents type and quantity and energyrequirements will be collected and then used as input information to simulate the potential impacts.